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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1affects response to substanceISOGpx1 (Mus musculus)6480464CTDGPX1 protein affects the susceptibility to MethamphetaminePMID:34082047
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDGPX1 protein affects the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]; GPX1 protein affects the reaction [Methamphetamine results in increased activity of RELA protein]; Methamphetamine affects the expression of and affects the activity of GPX1 protein; pyrrolidine dithiocarbamic acid affects the reaction [GPX1 protein affects the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]]PMID:34082047
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