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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases expressionEXP 6480464CTDbisphenol S results in decreased expression of GPX1 mRNAPMID:37357847
Gpx1multiple interactionsEXP 6480464CTD[bisphenol S co-treated with diethyl phthalate] results in decreased activity of GPX1 protein; morin inhibits the reaction [[bisphenol S co-treated with diethyl phthalate] results in decreased activity of GPX1 protein]PMID:35900689
Gpx1increases expressionISOGpx1 (Mus musculus)6480464CTDbisphenol S results in increased expression of GPX1 mRNAPMID:37286763
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTD[bisphenol S co-treated with Tretinoin] results in decreased expression of GPX1 mRNAPMID:30951980
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