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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1decreases activityEXP 6480464CTDArsenic Trioxide results in decreased activity of GPX1 proteinPMID:29986281
Gpx1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of GPX1 proteinPMID:29986281
Gpx1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of GPX1 mRNAPMID:29986281
Gpx1decreases activityISOGPX1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of GPX1 proteinPMID:16867262
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