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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:28838
Term: lutein
Definition: A carotenol that has formula C40H56O2.
Chemical ID: MESH:D014975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1increases expressionISOGpx1 (Mus musculus)6480464CTDLutein results in increased expression of GPX1 mRNAPMID:24865317
Gpx1multiple interactionsISOGpx1 (Mus musculus)6480464CTDCisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]PMID:22040935 PMID:24865317
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