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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2726
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpd2
Name: glycerol-3-phosphate dehydrogenase 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpd2decreases expressionISOGPD2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of GPD2 mRNAPMID:23179753 PMID:25716160 PMID:27188386 PMID:29501571 PMID:37505509
Gpd2increases methylationISOGPD2 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of GPD2 genePMID:29154799 PMID:29501571
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