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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1affects localizationEXP 6480464CTDEndosulfan affects the localization of GJA1 proteinPMID:8020150
Gja1decreases expressionEXP 6480464CTDEndosulfan results in decreased expression of GJA1 mRNA; Endosulfan results in decreased expression of GJA1 proteinPMID:11767051 PMID:29391264
Gja1decreases phosphorylationEXP 6480464CTDEndosulfan results in decreased phosphorylation of GJA1 proteinPMID:8020150
Gja1increases phosphorylationEXP 6480464CTDEndosulfan results in increased phosphorylation of GJA1 proteinPMID:8020150
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDEndosulfan results in decreased expression of GJA1 mRNA; Endosulfan results in decreased expression of GJA1 proteinPMID:28108160
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