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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of GJA1 proteinPMID:15082077
Gja1decreases expressionISOGja1 (Mus musculus)6480464CTDCisplatin results in decreased expression of GJA1 mRNA; Cisplatin results in decreased expression of GJA1 proteinPMID:21151649 PMID:24449132
Gja1increases expressionISOGja1 (Mus musculus)6480464CTDCisplatin results in increased expression of GJA1 proteinPMID:34785303
Gja1increases expressionISOGJA1 (Homo sapiens)6480464CTDCisplatin results in increased expression of GJA1 proteinPMID:34785303
Gja1increases phosphorylationISOGja1 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of GJA1 proteinPMID:22006019
Gja1multiple interactionsISOGja1 (Mus musculus)6480464CTDgap 27 peptide inhibits the reaction [Cisplatin results in increased expression of GJA1 protein]PMID:34785303
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTDgap 27 peptide inhibits the reaction [Cisplatin results in increased expression of GJA1 protein]; GJA1 protein affects the reaction [Cisplatin results in decreased expression of BCL2 protein]; GJA1 protein affects the reaction [Cisplatin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [Cisplatin results in increased cleavage of CASP3 protein]; GJA1 protein affects the reaction [Cisplatin results in increased expression of BAX protein]PMID:34785303
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