Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2690
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Gja1
Name:	gap junction protein, alpha 1

Acc ID:	CHEBI:27881
Term:	resveratrol
Definition:	A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID:	MESH:C059514

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Gja1	multiple interactions	EXP		6480464	CTD	Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Resveratrol affects the phosphorylation of and affects the localization of GJA1 protein; Resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]; Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GJA1 protein]; Resveratrol promotes the reaction [CHRM3 protein binds to GJA1 protein]	PMID:10973802 PMID:17520802 PMID:19720069 PMID:24079413 PMID:28713934
Gja1	decreases expression	ISO	Gja1 (Mus musculus)	6480464	CTD	resveratrol results in decreased expression of GJA1 mRNA	PMID:22610192
Gja1	increases expression	ISO	Gja1 (Mus musculus)	6480464	CTD	Resveratrol results in increased expression of GJA1 mRNA; Resveratrol results in increased expression of GJA1 protein	PMID:24449132
Gja1	multiple interactions	ISO	Gja1 (Mus musculus)	6480464	CTD	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of GJA1 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased expression of GJA1 protein]; Resveratrol inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Resveratrol results in increased expression of GJA1 protein]	PMID:24449132 PMID:27260466
Gja1	multiple interactions	ISO	GJA1 (Homo sapiens)	6480464	CTD	[Plant Extracts co-treated with Resveratrol] results in decreased expression of GJA1 mRNA; Resveratrol inhibits the reaction [Glucose results in increased degradation of GJA1 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]	PMID:20578705 PMID:23452621 PMID:23557933

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