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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2690
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDDDT results in decreased expression of GJA1 protein; DDT results in decreased expression of GJA1 protein modified formPMID:15082077
Gja1increases degradationEXP 6480464CTDDDT results in increased degradation of GJA1 protein; DDT results in increased degradation of GJA1 protein modified formPMID:8313522 PMID:8824497
Gja1multiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; DDT results in decreased expression of and results in increased phosphorylation of GJA1 proteinPMID:8285856 PMID:8824497
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDDDT results in decreased expression of GJA1 proteinPMID:8820588
Gja1increases expressionISOGja1 (Mus musculus)6480464CTDDDT results in increased expression of GJA1 protein modified formPMID:35413382
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTD[DDT co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 proteinPMID:8820588
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