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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2674
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15increases expressionISOGDF15 (Homo sapiens)6480464CTDDactinomycin results in increased expression of GDF15 mRNAPMID:38460933
Gdf15multiple interactionsISOGDF15 (Homo sapiens)6480464CTD[Dactinomycin co-treated with nutlin 3] results in increased expression of GDF15 mRNA; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of GDF15 mRNA]PMID:17257620 PMID:38460933
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