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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2670
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gck
Name: glucokinase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gckaffects expressionEXP 6480464CTDbisphenol A affects the expression of GCK mRNAPMID:32145629
Gckdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GCK mRNAPMID:22946080 PMID:23328667 PMID:24793715 PMID:25181051 PMID:37570835
Gckincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of GCK gene; bisphenol A results in increased methylation of GCK promoterPMID:23748860 PMID:24793715 PMID:28505145
Gckmultiple interactionsEXP 6480464CTD[bisphenol A results in increased methylation of GCK promoter] which results in decreased expression of GCK mRNA; Resveratrol inhibits the reaction [bisphenol A results in decreased expression of GCK mRNA]PMID:23748860 PMID:37570835
Gckdecreases expressionISOGCK (Homo sapiens)6480464CTDbisphenol A results in decreased expression of GCK mRNAPMID:31121516
Gckincreases expressionISOGck (Mus musculus)6480464CTDbisphenol A results in increased expression of GCK mRNA; bisphenol A results in increased expression of GCK proteinPMID:21932408 PMID:30566610 PMID:32156529 PMID:33221593 PMID:36674557
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