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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2652
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:32168
Term: sulpiride
Definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Chemical ID: MESH:D013469
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1decreases methylationISOGad1 (Mus musculus)6480464CTDSulpiride results in decreased methylation of GAD1 promoterPMID:18757738
Gad1multiple interactionsISOGad1 (Mus musculus)6480464CTDValproic Acid promotes the reaction [Sulpiride results in decreased methylation of GAD1 promoter]PMID:18757738
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