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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2652
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1increases expressionEXP 6480464CTDAmphetamine results in increased expression of GAD1 mRNA; Amphetamine results in increased expression of GAD1 proteinPMID:14725721 PMID:18312583
Gad1multiple interactionsEXP 6480464CTDAmphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]; Propranolol inhibits the reaction [Amphetamine inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]]PMID:8774452
Gad1affects expressionISOGad1 (Mus musculus)6480464CTDAmphetamine affects the expression of GAD1 proteinPMID:19059431
Gad1increases expressionISOGad1 (Mus musculus)6480464CTDAmphetamine results in increased expression of GAD1 mRNAPMID:23660488
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