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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2630
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fshb
Name: follicle stimulating hormone subunit beta
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshbdecreases secretionEXP 6480464CTDCyclophosphamide results in decreased secretion of FSHB proteinPMID:25446862 PMID:32197949
Fshbincreases expressionEXP 6480464CTDCyclophosphamide results in increased expression of FSHB proteinPMID:32456565 PMID:36154502
Fshbmultiple interactionsEXP 6480464CTDCilostazol inhibits the reaction [Cyclophosphamide results in increased expression of FSHB protein]; Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of FSHB protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein]PMID:32197949 PMID:32456565 PMID:36154502
Fshbincreases expressionISOFSHB (Homo sapiens)6480464CTDCyclophosphamide results in increased expression of FSHB proteinPMID:6788612
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