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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fosl1
Name: FOS like 1, AP-1 transcription factor subunit
Acc ID: CHEBI:7542
Term: neurotensin
Definition: A 13 amino acid peptide hormone which is found in the central nervous system and the gastrointestinal tract. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a neuromodulator. It is implicated in the pathophysiology of several CNS disorders (including schizophrenia, Parkinson's disease, drug abuse, pain, cancer, inflammation, eating disorders and central control of blood pressure) due to its association with a wide variety of neurotransmitter systems such as dopaminergic, sertonergic, glutamatergic, GABAergic, and cholinergic systems.
Chemical ID: MESH:D009496
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosl1increases activityISOFOSL1 (Homo sapiens)6480464CTDNeurotensin results in increased activity of FOSL1 proteinPMID:17000667
Fosl1multiple interactionsISOFOSL1 (Homo sapiens)6480464CTD[Neurotensin results in increased activity of FOSL1 protein] which results in increased expression of CXCL8 proteinPMID:17000667
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