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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:7565
Term: nifedipine
Definition: A dihydropyridine that has formula C17H18N2O6.
Chemical ID: MESH:D009543
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDNifedipine results in decreased expression of FOS proteinPMID:7534335
Fosmultiple interactionsEXP 6480464CTD[Nifedipine co-treated with omega-Conotoxin GVIA co-treated with omega-Agatoxin IVA] inhibits the reaction [Potassium Chloride affects the expression of FOS mRNA]; Nifedipine affects the reaction [Haloperidol results in increased expression of FOS protein]; Nifedipine inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]PMID:17913375 PMID:20211981 PMID:7534335
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDNifedipine inhibits the reaction [FGF2 protein results in increased expression of FOS mRNA]PMID:16188231
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