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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosincreases expressionEXP 6480464CTDMethamphetamine results in increased expression of FOS mRNA; Methamphetamine results in increased expression of FOS proteinPMID:10731628 PMID:11754491 PMID:19564919 PMID:20731630
Fosmultiple interactionsEXP 6480464CTD[Methamphetamine co-treated with SCH 23390] results in increased expression of FOS mRNA; Carbamazepine inhibits the reaction [Methamphetamine results in increased expression of FOS protein]; Oxytocin inhibits the reaction [Methamphetamine results in increased expression of FOS protein]PMID:10731628 PMID:19564919 PMID:20731630
Fosaffects response to substanceISOFos (Mus musculus)6480464CTDFOS mRNA affects the susceptibility to Methamphetamine; FOS protein affects the susceptibility to MethamphetaminePMID:10559418 PMID:12050851 PMID:19689456
Fosincreases expressionISOFos (Mus musculus)6480464CTDMethamphetamine results in increased expression of FOS; Methamphetamine results in increased expression of FOS proteinPMID:10559418 PMID:20950675
Fosmultiple interactionsISOFos (Mus musculus)6480464CTDBee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]; FOS protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; Idazoxan inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]; Lidocaine inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]]PMID:10559418 PMID:20950675
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