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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2620
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Flg
Name: filaggrin
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Flgdecreases expressionISOFLG (Homo sapiens)6480464CTDEstradiol results in decreased expression of FLG mRNAPMID:28701262
Flgincreases expressionISOFlg (Mus musculus)6480464CTDEstradiol results in increased expression of FLG mRNAPMID:19484750
Flgmultiple interactionsISOFLG (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of FLG mRNA; [FLG gene mutant form affects the susceptibility to 2,4-dihydroxybenzophenone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to bisphenol A] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of FLG mRNA]PMID:28701262 PMID:30165855 PMID:30245359
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