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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2615
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fhl1
Name: four and a half LIM domains 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fhl1affects expressionEXP 6480464CTDbisphenol A affects the expression of FHL1 mRNAPMID:32145629
Fhl1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of FHL1 mRNAPMID:18180321 PMID:25181051
Fhl1decreases expressionISOFhl1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of FHL1 mRNAPMID:37105096
Fhl1decreases expressionISOFHL1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of FHL1 mRNA; bisphenol A results in decreased expression of FHL1 proteinPMID:22576693 PMID:27685785 PMID:31675489 PMID:34186270
Fhl1increases methylationISOFHL1 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of FHL1 genePMID:22576693
Fhl1multiple interactionsISOFhl1 (Mus musculus)6480464CTD[Dextran Sulfate co-treated with bisphenol A] results in decreased expression of FHL1 proteinPMID:35999755
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