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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2590
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fabp1
Name: fatty acid binding protein 1
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fabp1increases expressionEXP 6480464CTDBezafibrate results in increased expression of FABP1 mRNA; Bezafibrate results in increased expression of FABP1 proteinPMID:2328261
Fabp1multiple interactionsEXP 6480464CTD2-tetradecylglycidic acid inhibits the reaction [Bezafibrate results in increased expression of FABP1 protein]; Bezafibrate inhibits the reaction [Oleic Acid binds to FABP1 protein]PMID:2328261
Fabp1decreases expressionISOFABP1 (Homo sapiens)6480464CTDBezafibrate results in decreased expression of FABP1 mRNAPMID:15708366
Fabp1increases expressionISOFabp1 (Mus musculus)6480464CTDBezafibrate results in increased expression of FABP1 mRNA; Bezafibrate results in increased expression of FABP1 proteinPMID:10191295 PMID:12782154 PMID:16574099 PMID:17118139 PMID:22338096
Fabp1increases expressionISOFABP1 (Homo sapiens)6480464CTDBezafibrate results in increased expression of FABP1 mRNAPMID:18368030
Fabp1multiple interactionsISOFabp1 (Mus musculus)6480464CTDButyrates promotes the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein]PMID:12782154 PMID:22338096
Fabp1multiple interactionsISOFABP1 (Homo sapiens)6480464CTD[Cisplatin co-treated with Bezafibrate] results in increased expression of FABP1 mRNA; Bezafibrate affects the localization of and results in increased expression of FABP1 protein; Bezafibrate inhibits the reaction [Cisplatin results in decreased expression of FABP1 protein]PMID:18368030
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