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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:165198
Term: Bisphenol Z
Definition: null
Chemical ID: MESH:C517113
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDbisphenol Z binds to ESR1 proteinPMID:30143207 PMID:31836225
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDbisphenol Z results in increased activity of ESR1 proteinPMID:30582956 PMID:30951782 PMID:31388671
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDbisphenol Z results in increased expression of ESR1 proteinPMID:38133387
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[bisphenol Z co-treated with bisphenol A] results in increased expression of ESR1 protein; bisphenol Z binds to and results in decreased activity of ESR1 protein; bisphenol Z binds to and results in increased activity of ESR1 protein; bisphenol Z inhibits the reaction [Estradiol binds to ESR1 protein]; Fulvestrant inhibits the reaction [bisphenol Z results in increased activity of ESR1 protein]PMID:28591870 PMID:29392883 PMID:31195007 PMID:31388671 PMID:32387340 PMID:38133387
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