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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:64153
Term: tanespimycin
Definition: A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
Chemical ID: MESH:C112765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrdecreases expressionISOEGFR (Homo sapiens)6480464CTDtanespimycin analog results in decreased expression of EGFR protein; tanespimycin results in decreased expression of EGFR proteinPMID:17010675 PMID:22810956 PMID:31370342
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTDtanespimycin results in increased degradation of and results in decreased expression of EGFR proteinPMID:16061882
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