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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:18123
Term: N-methylnicotinate
Definition: An iminium betaine that is the conjugate base of N-methylnicotinic acid, arising from deprotonation of the carboxy group.
Chemical ID: MESH:C009560
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrdecreases phosphorylationISOEGFR (Homo sapiens)6480464CTDtrigonelline results in decreased phosphorylation of EGFR proteinPMID:33148531
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTDtrigonelline inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]PMID:33148531
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