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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ednra
Name: endothelin receptor type A
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ednramultiple interactionsISOEDNRA (Homo sapiens)6480464CTD[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNAPMID:19059307
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