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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:3011
Term: benazepril
Definition: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Chemical ID: MESH:C044946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1decreases expressionEXP 6480464CTDbenazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 proteinPMID:16191423
Edn1increases activityEXP 6480464CTDbenazepril results in increased activity of EDN1 proteinPMID:7528292
Edn1multiple interactionsEXP 6480464CTD[Valsartan co-treated with benazepril] results in decreased expression of EDN1 proteinPMID:11136700
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