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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2521
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd3
Name: dopamine receptor D3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd3affects expressionEXP 6480464CTDbisphenol A affects the expression of DRD3 mRNAPMID:26141625
Drd3decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of DRD3 mRNAPMID:25181051
Drd3increases expressionEXP 6480464CTDbisphenol A results in increased expression of DRD3 mRNAPMID:26141625
Drd3decreases activityISODrd3 (Mus musculus)6480464CTDbisphenol A results in decreased activity of DRD3 proteinPMID:16045194
Drd3multiple interactionsISODrd3 (Mus musculus)6480464CTDbisphenol A inhibits the reaction [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein]; bisphenol A inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 protein]PMID:15203435
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