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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2479
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4a2
Name: cytochrome P450, family 4, subfamily a, polypeptide 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4a2decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of CYP4A2 proteinPMID:19634143
Cyp4a2multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Streptozocin] results in increased expression of CYP4A2 mRNA; Trientine promotes the reaction [Streptozocin results in decreased expression of CYP4A2 protein]PMID:19634143 PMID:24815820
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