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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:6030
Term: isoniazide
Definition: A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine.
Chemical ID: MESH:D007538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityEXP 6480464CTDIsoniazid results in decreased activity of CYP2E1 proteinPMID:39047805
Cyp2e1increases activityEXP 6480464CTDIsoniazid results in increased activity of CYP2E1 proteinPMID:12458634 PMID:15132840 PMID:15205388 PMID:19683030 PMID:23211455 PMID:25683034 PMID:26880746 PMID:9051121 PMID:9129171
Cyp2e1increases expressionEXP 6480464CTDIsoniazid results in increased expression of CYP2E1; Isoniazid results in increased expression of CYP2E1 mRNA; Isoniazid results in increased expression of CYP2E1 proteinPMID:11752103 PMID:15205388 PMID:15763544 PMID:20566340 PMID:24929095 PMID:25683034 PMID:3113478 PMID:9065729
Cyp2e1multiple interactionsEXP 6480464CTD2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine]; Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; NADP promotes the reaction [Isoniazid results in decreased activity of CYP2E1 protein]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]PMID:12458634 PMID:15132840 PMID:18754103 PMID:19683030 PMID:20566340 PMID:26880746 PMID:27919644 PMID:39047805 PMID:7710944 PMID:9051121 PMID:9065729
Cyp2e1affects response to substanceISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 gene polymorphism affects the susceptibility to Isoniazid; CYP2E1 gene SNP affects the susceptibility to IsoniazidPMID:12668988 PMID:20485159
Cyp2e1decreases activityISOCyp2e1 (Mus musculus)6480464CTDIsoniazid results in decreased activity of CYP2E1 proteinPMID:39047805
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDIsoniazid results in decreased activity of CYP2E1 proteinPMID:39047805
Cyp2e1increases expressionISOCyp2e1 (Mus musculus)6480464CTDIsoniazid results in increased expression of CYP2E1 mRNAPMID:22342832
Cyp2e1increases expressionISOCYP2E1 (Homo sapiens)6480464CTDIsoniazid results in increased expression of CYP2E1 proteinPMID:8074729
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of IsoniazidPMID:17950035
Cyp2e1increases response to substanceISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased susceptibility to IsoniazidPMID:28762043
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[Isoniazid co-treated with Rifampin co-treated with dendrobine] results in decreased expression of CYP2E1 mRNA; [Isoniazid co-treated with Rifampin] results in decreased expression of CYP2E1 mRNA; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]; NADP promotes the reaction [Isoniazid results in decreased activity of CYP2E1 protein]PMID:22342832 PMID:32633153 PMID:39047805
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDGSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]; NADP promotes the reaction [Isoniazid results in decreased activity of CYP2E1 protein]PMID:28762043 PMID:39047805
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