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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:47136
Term: pentachlorobenzene
Definition: A member of the class of pentachlorobenzenes that is benzene in which five of the hydrogens are replaced by chlorines. Now classed as a persistent organic pollutant under the Stockholm Convention.
Chemical ID: MESH:C003060
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases expressionEXP 6480464CTDpentachlorobenzene results in increased expression of CYP2E1 proteinPMID:10696772
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of pentachlorobenzenePMID:7747284
Cyp2e1increases oxidationISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased oxidation of pentachlorobenzenePMID:7747284
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