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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects metabolic processingEXP 6480464CTDCYP2E1 protein affects the metabolism of AcetaminophenPMID:15772367
Cyp2e1decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CYP2E1 mRNAPMID:17126469 PMID:21807079 PMID:33387578
Cyp2e1increases activityEXP 6480464CTDAcetaminophen results in increased activity of CYP2E1 proteinPMID:19932728
Cyp2e1increases expressionEXP 6480464CTDAcetaminophen results in increased expression of CYP2E1 mRNA; Acetaminophen results in increased expression of CYP2E1 proteinPMID:18798224 PMID:33350580
Cyp2e1increases response to substanceEXP 6480464CTDCYP2E1 protein results in increased susceptibility to AcetaminophenPMID:21130154
Cyp2e1multiple interactionsEXP 6480464CTD[Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP2E1 mRNA; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein; Acetaminophen results in increased phosphorylation of and results in increased activity of CYP2E1 protein; Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]; Choline deficiency promotes the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Uranium analog promotes the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; YH 439 inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of CYP2E1 protein]PMID:11562448 PMID:17126469 PMID:18798224 PMID:19932728 PMID:20566340 PMID:21170329 PMID:33350580
Cyp2e1affects expressionISOCyp2e1 (Mus musculus)6480464CTDAcetaminophen affects the expression of CYP2E1 mRNAPMID:17562736
Cyp2e1affects response to substanceISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein affects the susceptibility to AcetaminophenPMID:19256530
Cyp2e1decreases activityISOCyp2e1 (Mus musculus)6480464CTDAcetaminophen results in decreased activity of CYP2E1 proteinPMID:26772156 PMID:35948136
Cyp2e1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of CYP2E1 mRNA; Acetaminophen results in decreased expression of CYP2E1 proteinPMID:15576447 PMID:21329376 PMID:22683606 PMID:29689376 PMID:35948136 PMID:36073954 PMID:37179516
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of CYP2E1 mRNA; Acetaminophen results in decreased expression of CYP2E1 proteinPMID:29067470 PMID:32112222
Cyp2e1increases activityISOCyp2e1 (Mus musculus)6480464CTDAcetaminophen results in increased activity of CYP2E1 proteinPMID:19256530 PMID:19799668 PMID:20166895 PMID:23333575 PMID:29325178
Cyp2e1increases expressionISOCyp2e1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of CYP2E1 mRNA; Acetaminophen results in increased expression of CYP2E1 proteinPMID:12958197 PMID:16393943 PMID:19002106 PMID:20067817 PMID:30423402 PMID:31967706 PMID:33271250
Cyp2e1increases expressionISOCYP2E1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of CYP2E1 mRNA; Acetaminophen results in increased expression of CYP2E1 proteinPMID:23728527 PMID:26690555 PMID:30567741 PMID:33811995
Cyp2e1increases metabolic processingISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein results in increased metabolism of AcetaminophenPMID:19002106
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of Acetaminophen; CYP2E1 results in increased metabolism of AcetaminophenPMID:12464242 PMID:15576447 PMID:20566340
Cyp2e1increases response to substanceISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein results in increased susceptibility to AcetaminophenPMID:11323178 PMID:16557553 PMID:19679878
Cyp2e1increases response to substanceISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased susceptibility to AcetaminophenPMID:11212141 PMID:28762043
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[Acetaminophen results in increased activity of CYP2E1 protein] inhibits the reaction [PPARA protein results in increased oxidation of Fatty Acids]; [Clofibrate co-treated with Acetaminophen] affects the expression of CYP2E1 mRNA; [IL33 protein affects the susceptibility to Acetaminophen] which affects the expression of CYP2E1 mRNA; Acetaminophen results in increased expression of and results in decreased activity of CYP2E1 protein; Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]; CYP2E1 protein affects the metabolism of and results in decreased abundance of Acetaminophen; CYP2E1 protein affects the reaction [Acetaminophen results in increased abundance of acylcarnitine]; CYP2E1 protein affects the reaction [Acetaminophen results in increased activity of PPARA protein]; CYP2E1 protein results in increased metabolism of and affects the susceptibility to Acetaminophen; CYP2E1 protein results in increased metabolism of and results in increased activity of Acetaminophen; dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; Genistein inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]; hyperoside inhibits the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]; IL1A protein inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; KITL protein inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2E1 mRNA]; PPARA protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; Saint John's wort extract inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; schizandrol B inhibits the reaction [CYP2E1 protein results in increased metabolism of and results in increased activity of Acetaminophen]; SLC13A1 protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Taurine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein]; Taurine inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; tetrahydrocurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]PMID:11376689 PMID:12594235 PMID:12958197 PMID:16729303 PMID:17585979 PMID:19002106 PMID:19256530 PMID:19679878 PMID:19799668 PMID:20067817 PMID:20166895 PMID:22683606 PMID:22939915 PMID:23333575 PMID:25319358 PMID:26772156 PMID:30423402 PMID:31967706 PMID:33887374 PMID:36073954
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen; Ethanol affects the reaction [CYP2E1 protein results in increased susceptibility to Acetaminophen]; GSTM1 protein inhibits the reaction [[CYP2E1 protein co-treated with CYP1A2 protein] results in increased susceptibility to Acetaminophen]; Oxygen deficiency inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; PPP2CA protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; PPP2R5A protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; PPP2R5A protein affects the reaction [Acetaminophen results in increased expression of CYP2E1 protein]PMID:11212141 PMID:28762043 PMID:30567741 PMID:33811995
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