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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects expressionEXP 6480464CTDCurcumin affects the expression of CYP2E1 proteinPMID:16805852
Cyp2e1increases expressionEXP 6480464CTDCurcumin results in increased expression of CYP2E1 mRNAPMID:18539377
Cyp2e1multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]PMID:33350580
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 mRNA]; Curcumin metabolite inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein]; Curcumin metabolite promotes the reaction [Acetaminophen results in decreased activity of CYP2E1 protein]PMID:30423402
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]PMID:24508477
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