GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2e1 | decreases activity | EXP | | 6480464 | CTD | 1,2-dichloroethylene results in decreased activity of CYP2E1 protein | PMID:15205388 PMID:20127315 PMID:9344893 PMID:9671540 | Cyp2e1 | decreases expression | EXP | | 6480464 | CTD | 1,2-dichloroethylene results in decreased expression of CYP2E1 protein | PMID:9671540 | Cyp2e1 | multiple interactions | EXP | | 6480464 | CTD | 1,2-dichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]; 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Trichloroethylene]; 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride] | PMID:7871537 PMID:9851676 | Cyp2e1 | decreases activity | ISO | CYP2E1 (Homo sapiens) | 6480464 | CTD | 1,2-dichloroethylene results in decreased activity of CYP2E1 protein | PMID:32199159 | Cyp2e1 | multiple interactions | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | 1,2-dichloroethylene inhibits the reaction [CYP2E1 protein results in increased oxidation of 1,3-butadiene] | PMID:10828257 | | ||||||||||||||||||||||
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