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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:9352
Term: sulindac
Definition: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Chemical ID: MESH:D013467
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1increases activityEXP 6480464CTDSulindac results in increased activity of CYP1B1 proteinPMID:16531450
Cyp1b1increases expressionEXP 6480464CTDSulindac results in increased expression of CYP1B1 mRNAPMID:16531450
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDSulindac results in decreased activity of CYP1B1 proteinPMID:33814510
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDSulindac results in increased expression of CYP1B1 mRNAPMID:17985343
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