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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDApigenin results in decreased activity of CYP1B1 proteinPMID:16271822 PMID:21482471
Cyp1b1increases chemical synthesisISOCYP1B1 (Homo sapiens)6480464CTDCYP1B1 protein results in increased chemical synthesis of ApigeninPMID:19666078
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDApigenin results in increased expression of CYP1B1 mRNAPMID:31621310
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTDApigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]PMID:20930378
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin; Apigenin binds to and results in decreased activity of CYP1B1 proteinPMID:19666078 PMID:21053930
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