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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:8887
Term: rofecoxib
Definition: A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Chemical ID: MESH:C116926
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDrofecoxib results in decreased activity of CYP1A2 proteinPMID:18816299
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDrofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]PMID:15834531 PMID:16934051
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