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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects expressionEXP 6480464CTDChlorpromazine affects the expression of CYP1A2 mRNAPMID:18246545
Cyp1a2increases expressionEXP 6480464CTDChlorpromazine results in increased expression of CYP1A2 mRNAPMID:25596134
Cyp1a2decreases methylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in decreased methylation of ChlorpromazinePMID:20615392
Cyp1a2decreases response to substanceISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in decreased susceptibility to ChlorpromazinePMID:26477383
Cyp1a2increases oxidationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased oxidation of ChlorpromazinePMID:20615392
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of ChlorpromazinePMID:18493746 PMID:19482014 PMID:23397584 PMID:27344345
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