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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34757
Term: fenitrothion
Definition: An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.
Chemical ID: MESH:D005278
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTDFenitrothion results in increased expression of CYP1A2 mRNAPMID:34802538
Cyp1a2multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Fenitrothion results in increased expression of CYP1A2 mRNA]PMID:34802538
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDFenitrothion results in decreased activity of CYP1A2 proteinPMID:20183062 PMID:22634058
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDFenitrothion results in increased expression of CYP1A2 mRNAPMID:22310298
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