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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsEXP 6480464CTD[Streptozocin results in increased expression of CYP1A2 protein] which results in increased metabolism of DiazinonPMID:17442507
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of DiazinonPMID:15557345 PMID:15764407
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDDiazinon results in increased expression of CYP1A2 mRNA; Diazinon results in increased expression of CYP1A2 proteinPMID:21784029
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in decreased sulfation of and results in increased activity of Diazinon; CYP1A2 protein results in increased metabolism of and results in increased activity of DiazinonPMID:11708902 PMID:15764407
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