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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNAPMID:20033131
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of MelatoninPMID:15626586 PMID:15824912
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDMelatonin results in decreased activity of CYP1A2 proteinPMID:19919601
Cyp1a2decreases methylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in decreased methylation of MelatoninPMID:15616152
Cyp1a2increases hydroxylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased hydroxylation of MelatoninPMID:15616152 PMID:22634058
Cyp1a2increases metabolic processingISOCyp1a2 (Mus musculus)6480464CTDCYP1A2 protein results in increased metabolism of MelatoninPMID:25623066
Cyp1a2increases metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased metabolism of MelatoninPMID:17565714
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]PMID:25623066
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDMelatonin inhibits the reaction [CYP1A2 protein results in increased hydrolysis of Benzo(a)pyrene]PMID:19919601
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