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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:27916
Term: 2'-hydroxychalcone
Definition: A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.
Chemical ID: MESH:C013031
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTD2'-hydroxychalcone results in decreased activity of CYP1A1 proteinPMID:15596260
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]PMID:15596260
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