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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:8434
Term: prochloraz
Definition: A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.
Chemical ID: MESH:C045362
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1increases expressionEXP 6480464CTDprochloraz results in increased expression of CYP19A1 mRNAPMID:37551828
Cyp19a1multiple interactionsEXP 6480464CTD[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP19A1 mRNAPMID:25607892
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDprochloraz results in decreased activity of CYP19A1 proteinPMID:10806373 PMID:11884232 PMID:15554355 PMID:16996190
Cyp19a1increases activityISOCYP19A1 (Homo sapiens)6480464CTDprochloraz results in increased activity of CYP19A1 proteinPMID:20087668
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTDprochloraz results in increased expression of CYP19A1 mRNAPMID:25233012 PMID:25765474
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD[prochloraz co-treated with Chlorpyrifos co-treated with triflusulfuron-methyl] results in increased expression of CYP19A1 mRNA; [prochloraz co-treated with epoxiconazole co-treated with cyproconazole] results in increased expression of CYP19A1 mRNAPMID:25233012
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