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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2451
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsincreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS proteinPMID:19576244
Cycsmultiple interactionsEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS mRNA]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of CYCS proteinPMID:19576244
Cycsincreases expressionISOCYCS (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS mRNA; 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS proteinPMID:19022289
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS mRNA]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYCS protein]PMID:19022289
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