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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Comt
Name: catechol-O-methyltransferase
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Comtmultiple interactionsISOCOMT (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [DNMT3B protein binds to COMT promoter]; sulforaphane inhibits the reaction [EP300 protein binds to COMT promoter]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [DNMT3B protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [HDAC1 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol promotes the reaction [MBD2 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]; sulforaphane inhibits the reaction [Estradiol results in increased methylation of COMT promoter]; sulforaphane inhibits the reaction [Genistein promotes the reaction [HDAC1 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Genistein promotes the reaction [MBD2 protein binds to COMT promoter]]; sulforaphane inhibits the reaction [Genistein results in decreased expression of COMT mRNA]; sulforaphane inhibits the reaction [Genistein results in increased methylation of COMT promoter]; sulforaphane inhibits the reaction [HDAC1 protein binds to COMT promoter]PMID:30684530
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