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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin-dependent kinase inhibitor 2A
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2adecreases expressionEXP 6480464CTDDDT results in decreased expression of CDKN2A mRNA alternative form; DDT results in decreased expression of CDKN2A protein alternative formPMID:25410620
Cdkn2aincreases methylationEXP 6480464CTDDDT results in increased methylation of CDKN2A promoter alternative formPMID:25410620
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