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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:41977
Term: daunorubicin
Definition: A natural product found in Actinomadura roseola.
Chemical ID: MESH:D003630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1decreases metabolic processingISOCBR1 (Homo sapiens)6480464CTDCBR1 gene SNP results in decreased metabolism of DaunorubicinPMID:19204081
Cbr1increases metabolic processingISOCBR1 (Homo sapiens)6480464CTDCBR1 protein results in increased metabolism of Daunorubicin; CBR1 results in increased metabolism of DaunorubicinPMID:20670211 PMID:30849340
Cbr1increases reductionISOCBR1 (Homo sapiens)6480464CTDCBR1 protein results in increased reduction of DaunorubicinPMID:18579125 PMID:25541467
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTD8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; [[Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin] which results in decreased chemical synthesis of daunorubicinol; [CBR1 protein results in increased reduction of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [CBR1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol; [Curcumin binds to and results in decreased activity of CBR1 protein] which results in decreased reduction of Daunorubicin; [S-Nitrosoglutathione binds to CBR1 protein] inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]PMID:20670211 PMID:23295225 PMID:25541467 PMID:30849340
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