GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cav1 | increases expression | ISO | Cav1 (Mus musculus) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of CAV1 mRNA; Hydrogen Peroxide results in increased expression of CAV1 protein | PMID:12134086 PMID:17108117 | Cav1 | increases expression | ISO | CAV1 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of CAV1 mRNA; Hydrogen Peroxide results in increased expression of CAV1 protein | PMID:18385095 | Cav1 | increases phosphorylation | ISO | CAV1 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased phosphorylation of CAV1 protein | PMID:23246481 PMID:25512378 | Cav1 | increases response to substance | ISO | CAV1 (Homo sapiens) | 6480464 | CTD | CAV1 protein results in increased susceptibility to Hydrogen Peroxide | PMID:12640124 | Cav1 | multiple interactions | ISO | Cav1 (Mus musculus) | 6480464 | CTD | [Hydrogen Peroxide co-treated with CAV1 protein] results in increased expression of CDKN1A protein; CAV1 gene mutant form inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TRP53 protein]; CAV1 protein affects the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of IL6 protein]; CAV1 protein affects the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]; CAVIN1 protein affects the reaction [Hydrogen Peroxide promotes the reaction [MDM1 protein binds to CAV1 protein]]; Hydrogen Peroxide promotes the reaction [MDM1 protein binds to CAV1 protein]; Hydrogen Peroxide promotes the reaction [SP1 protein binds to CAV1 promoter]; Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 protein]; SIRT1 mutant form inhibits the reaction [CAV1 gene mutant form inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TRP53 protein]]; SIRT1 protein affects the reaction [CAV1 protein affects the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]]; TRP53 gene mutant form inhibits the reaction [[Hydrogen Peroxide co-treated with CAV1 protein] results in increased expression of CDKN1A protein]; Vitamin E inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 protein] | PMID:12134086 PMID:17108117 PMID:21705337 PMID:25512378 | Cav1 | multiple interactions | ISO | CAV1 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide inhibits the reaction [Acetylcysteine results in increased ubiquitination of and results in increased degradation of CAV1 protein]; Hydrogen Peroxide promotes the reaction [CAVIN1 protein binds to CAV1 protein]; Hydrogen Peroxide promotes the reaction [SIRT1 protein binds to CAV1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CAV1 protein]; SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein]; wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide] | PMID:12640124 PMID:17108117 PMID:18385095 PMID:21148404 PMID:21705337 PMID:23246481 PMID:25512378 | | ||||||||||||||||||||||
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