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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catincreases activityEXP 6480464CTDAsbestos, Crocidolite results in increased activity of CAT proteinPMID:1316905
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDCAT protein inhibits the reaction [Asbestos, Crocidolite results in increased mutagenesis of CD59 gene]; CAT protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of EGFR protein]; CAT protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK1 protein]; CAT protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK3 protein]PMID:12361925 PMID:16908449
Catmultiple interactionsISOCat (Mus musculus)6480464CTDCAT protein inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of MAPK7 protein]PMID:14737115
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