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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDMethotrexate results in decreased activity of CAT proteinPMID:28479099 PMID:37866152
Catdecreases expressionEXP 6480464CTDMethotrexate results in decreased expression of CAT proteinPMID:33720507
Catincreases activityEXP 6480464CTDMethotrexate results in increased activity of CAT proteinPMID:23424212 PMID:29069929
Catmultiple interactionsEXP 6480464CTD[agomelatine co-treated with Methotrexate] results in increased activity of CAT protein; [Aspartame co-treated with Methotrexate] results in increased activity of CAT protein; Chlorogenic Acid inhibits the reaction [Methotrexate results in decreased activity of CAT protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in decreased activity of CAT protein]; Methotrexate inhibits the reaction [Methotrexate results in increased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein]; sinapinic acid inhibits the reaction [Methotrexate results in decreased expression of CAT protein]PMID:23424212 PMID:25009784 PMID:28479099 PMID:31975554 PMID:32061742 PMID:33720507 PMID:37866152
Catincreases expressionISOCAT (Homo sapiens)6480464CTDMethotrexate results in increased expression of CAT mRNAPMID:17400583
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDEPO protein inhibits the reaction [Methotrexate results in increased activity of CAT protein]; SOD2 protein polymorphism affects the reaction [Methotrexate affects the expression of CAT mRNA]PMID:25330300 PMID:29069929
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