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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDAcrylamide results in decreased activity of CAT proteinPMID:25858877 PMID:28056603 PMID:36598108
Catdecreases expressionEXP 6480464CTDAcrylamide results in decreased expression of CAT proteinPMID:25934431
Catincreases activityEXP 6480464CTDAcrylamide results in increased activity of CAT proteinPMID:29913234
Catincreases expressionEXP 6480464CTDAcrylamide results in increased expression of CAT mRNAPMID:22459607 PMID:28959563
Catmultiple interactionsEXP 6480464CTD[Acrylamide co-treated with Aluminum Chloride] results in decreased activity of CAT protein; [Aluminum Chloride co-treated with Acrylamide] results in decreased expression of CAT protein; boric acid inhibits the reaction [Acrylamide results in increased activity of CAT protein]; epigallocatechin gallate inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]PMID:25858877 PMID:25934431 PMID:28056603 PMID:29913234 PMID:36598108
Catdecreases activityISOCAT (Homo sapiens)6480464CTDAcrylamide results in decreased activity of CAT proteinPMID:28159594
Catdecreases activityISOCat (Mus musculus)6480464CTDAcrylamide results in decreased activity of CAT proteinPMID:31081568 PMID:34896238 PMID:34906654
Catdecreases expressionISOCAT (Homo sapiens)6480464CTDAcrylamide results in decreased expression of CAT mRNAPMID:28159594
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDsalvin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of CAT mRNA]PMID:28159594
Catmultiple interactionsISOCat (Mus musculus)6480464CTDAcrylamide promotes the reaction [Streptozocin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]PMID:31081568 PMID:34896238
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