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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catmultiple interactionsEXP 6480464CTDhesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]PMID:19222219 PMID:19497424 PMID:21134734 PMID:34922902
Catdecreases activityISOCAT (Homo sapiens)6480464CTDhesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT proteinPMID:22142698
Catincreases activityISOCat (Mus musculus)6480464CTDhesperetin results in increased activity of CAT proteinPMID:19023542
Catmultiple interactionsISOCat (Mus musculus)6480464CTDhesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]PMID:26546711
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